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CRIXIVAN may interact with some drugsthereforepatients should be advised to report to their doctor the use of any other prescriptionnon-prescription medication or herbal productsparticularly StJohn’s wort.

Indinavir is a type of anti-HIV drug called a protease inhibitorThe most common side effects of indinavir can include nauseaheadachediarrheavomitingand weaknessIndinavir can also cause kidney stonesbut drinking a minimum of 1.5 litres of water dailyin addition to your regular intake of other fluidscan help reduce this complication.

Initiation of CRIXIVANa CYP3A inhibitorin patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving CRIXIVANmay increase plasma concentrations of medications metabolized by CYP3AInitiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of CRIXIVANrespectivelyThese interactions may lead to:

Body As A Wholeredistribution/accumulation of body fatsee PRECAUTIONSFat Redistribution

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indinavir is a substrate of cyp3a4 and p-glycoprotein p-gp ; ritonavir inhibits both cyp3a4 and p-gp.